NFL Football BETTING PREVIEW - Indianapolis Colts @ Tennessee Titans

NFL Football

2025-09-21 - Indianapolis Colts at Tennessee Titans

A Sports Betting Preview by FirstDown

Indianapolis Colts @ Tennessee Titans
United States : NFL Week 3
Sunday 21st September 2025 - Scheduled 1pm
6pm (British Time)

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Preview

They have missed the Playoffs in four straight seasons, but there is little doubt that the Indianapolis Colts (2-0) are heading into the 2025 season looking to put a big year together for former owner Jim Irsay.

The unexpected passing of Irsay in May will provide motivation for the team and fans and the Indianapolis Colts have looked good through the first two weeks of the season.

A mistake by the Denver Broncos allowed the Colts to re-kick a game winning Field Goal in Week 2 to remain perfect, but there is some caution to the start. Twelve months ago the New Orleans Saints looked pretty special through two games, but they did not make the post-season and the Colts have to remain focused as they begin Divisional play.

The Jacksonville Jaguars are 1-1, but Indianapolis begin by facing the Tennessee Titans (0-2) who have shown some competitive spirit, but ended 2024 with a 3-14 record. They pushed the Denver Broncos and Los Angeles Rams, but the Titans have failed to put a full game together and Head Coach Brian Callahan will soon be under serious pressure.

Cam Ward is the Number 1 Overall Pick, but he is playing behind a banged up Offensive Line and the skill players around him have not been up to the standard that may have been expected.

The Quarter Back is not helped by the fact that the Offensive Line is missing key players that may have helped to establish the run and at least put him in a position to not have to hold the ball for too long. Instead Cam Ward needs routes to develop and he has been under siege behind Center, which is something that even this limited Indianapolis pass rush could exploit.

There has been some room to run against the Indianapolis Colts Defensive Line, but the game plan may be to lock down the Titans up front and dare Cam Ward and the Receivers to beat them. Some of what Cam Ward has thrown up has looked good, but the plays are not being made and the Colts Secondary have begun the season in good form.

Tennessee are sure they have a franchise Quarter Back, but Indianapolis surprisingly chose Daniel Jones over Anthony Richardson as the starting Quarter Back.

Daniel Jones has made sure there has been no early regret about the decision and Anthony Richardson could potentially have to rebuild his career away from the Colts. The former has come out and led the Colts to two games without needing to Punt the ball away, although a huge helping hand has been given to Jones and the entire Offensive unit by Running Back Jonathan Taylor.

Credit should also be given to the Indianapolis Offensive Line that have opened up some big holes for Taylor to attack and they should be able to keep that positive start going when playing on the road for the first time in 2025.

Keeping Daniel Jones in front of the chains should make life pretty comfortable for the Indianapolis Colts and the Quarter Back should be able to make plays with his arm. He has been given time by the Offensive Line and Jones has eaten up the blitz, while playing out of third and manageable should mean the Colts are in a position to continue their fine start to the new season.

The Colts have won four in a row in this series with this AFC South rival and they have covered in all of those wins too, twice as the favourite.

The 2025 New Orleans Saints are a cautionary tale about fast starting teams, especially those that have been unexpected early successes, but this Indianapolis Colts team looks well balanced. They also do benefit from the schedule by playing in the AFC South, and the Indianapolis Colts can prove themselves as a genuine Playoff contender by producing better than their 0-3 record against the spread when set as the road favourite last season.

Indianapolis can change that narrative immediately by getting the better of a struggling rival and the Colts may have the Offensive power to come away with a strong win.

Prediction

Lay the points with the road favourite in this AFC South clash.

The Pick :

Tennessee Titans 17-27 Indianapolis Colts

FIXED ODDS BETTING :

I'll back Indianapolis Colts - 4 Points at -110 with Bookmaker.eu