NFL Football BETTING PREVIEW - San Francisco 49ers @ New York Giants

NFL Football

2025-11-02 - San Francisco 49ers at New York Giants

A Sports Betting Preview by FirstDown

San Francisco 49ers @ New York Giants
United States : NFL Week 9
Sunday 2nd November 2025 - Scheduled 1pm
6pm (British Time)

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Preview

Two teams that have major names out through injury face one another in Week 9 of the 2025 season, but it is 'next man up' situations for both.

The San Francisco 49ers (5-3) are still very much in contention in the NFC West, although it is a much tougher turnaround for the New York Giants (2-6).

Once again it is Mac Jones who will be playing at Quarter Back even though Brock Purdy is edging closer and closer to a return. It is the second consecutive road game for the 49ers who were beaten at the Houston Texans last week, but that was a tough match up for them, especially on the Offensive side of the ball.

It is not expected to be the same challenge for Mac Jones and the 49ers in this one and the Offensive Line is certainly going to feel they can open up some running lanes for Christian McCaffrey. The season has been one of inconsistency when it comes to pounding the rock, but the 49ers will not have played too many teams that give up the amount of yardage on the ground that the New York Giants have allowed.

You would have to lean towards the 49ers being successful rather than the Giants finding a way to clamp down on the run and this is going to make life more comfortable for Mac Jones who has not had too many of his top skill players available at the same time.

Being able to throw from third and manageable spots will help and there are areas to exploit in this Giants Secondary.

This is something that Mac Jones has shown he can do and the 49ers can keep the chains moving with a lot more consistency than they could against a tough Houston Defense last week.

Since Jaxson Dart took over at Quarter Back, the New York Giants have won both home games played, but the team have lost Cam Skattebo to a season ending injury after the rookie Running Back had given them a big spark. Malik Nabers is already out and you do have to wonder if the Giants have enough emotional energy to help them through this difficult time.

Recent games have seen the New York Giants produce inconsistent running numbers, but Cam Skattebo's energy was a huge boost for the team. Tyrone Tracy Jr can step in, but he is not expected to have a lot of room up front against this San Francisco Defensive Line, which has remained pretty solid even as the pass rushers continue to go down with injuries.

They are trying to bring in players to give that pass rush a boost, but it should mean Jaxson Dart has a bit more time to throw the ball when he drops back. However, the injuries to key players on this side of the ball may just lead to some inconsistency, even against this banged up San Francisco Secondary.

Ultimately that is where the 49ers may eventually do enough to secure an important road game and with the likelihood that they can establish the run better than they have for much of the season.

It is unlikely to be a blowout, but the road team can do enough to win this one and cover the spread set.

Prediction

Lay the points with the road favourite.

The Pick :

New York Giants 20-24 San Francisco 49ers

FIXED ODDS BETTING :

I'll back San Francisco 49ers - 2.5 Points at -110 with EveryGame Sportsbook