MLB Baseball BETTING PREVIEW - Minnesota Twins @ Chicago White Sox

MLB Baseball

2026-05-26 - Minnesota Twins at Chicago White Sox

A Sports Betting Preview by FirstDown

Minnesota Twins @ Chicago White Sox
United States : Major League Baseball
Tuesday 26th May 2026 - Scheduled 7:40pm EST
00:40am (British Time)

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Preview

The early American League Central standings feels very different to how it was imagined to be in pre-season with the Cleveland Guardians leading the Division and the Detroit Tigers at the bottom of this five team table.

In between, the Chicago White Sox (27-26) have perhaps been the biggest surprise as the team sit in 2nd place and just 3.5 games behind the Guardians.

Then comes the Minnesota Twins (26-28) as they look to bounce back in this series following the defeat on Monday. That loss means the Twins have been beaten in seven in a row by the Chicago White Sox, but there will be a real feeling that the run can be snapped when you think of the pitchers going to the mound.

The Minnesota Twins will turn to Joe Ryan who has a 3-3 record and 3.02 ERA from eleven starts made in 2026. The sixth year pitcher has become a pretty consistent figure on the mound for the Minnesota Twins and his current trajectory has Joe Ryan setting a new personal best record, although the season remains a long one to navigate.

Joe Ryan has not given up more than two runs in any of the last five starts, but he was handed the decision loss in the first of those at the end of April.

May has proven to be a happy hunting ground for Joe Ryan, who is set to pitch for the last time this month with a 1-0 record and a 1.47 ERA in four starts already made. The starter has given the Minnesota Twins a chance and they will be hoping that is the case against this Divisional rival with Joe Ryan bringing in a 3-0 record and 3.41 ERA from six career starts against the Chicago White Sox.

The home team will be countering with Sean Burke, but the Chicago White Sox will be hoping the third year pitcher can at least fight through what has been a difficult stretch.

Sean Burke has a 2-3 record and 4.08 ERA in ten appearances for the Chicago White Sox in 2026 and eight of those have been in starts. However, Sean Burke has not been able to complete 5 Innings in any of the last three starts and he has a 0-1 record and 8.10 ERA in those, which will have dented the confidence.

That may be difficult to change in this match up against the Minnesota Twins- the White Sox have a good record against this American League Central rival, but Sean Burke only recorded one out into the Fifth Inning in his sole start against the Twins and he allowed six runs in that time.

Unsurprisingly, Sean Burke was saddled with the decision loss in that outing in May 2025 in this ballpark.

Prediction

The Chicago White Sox have dominated the Minnesota Twins in recent games against one another and they have opened the 2026 season series with another victory.

However, it is Joe Ryan and the Twins who look to have the edge over Sean Burke and the former can set the table for a Minnesota win.

The Pick :

Chicago White Sox 2-6 Minnesota Twins

FIXED ODDS BETTING :

I'll back Minnesota Twins to Win at -109 with BetOnline