NFL Football
2025-09-28 - Indianapolis Colts at Los Angeles Rams
A Sports Betting Pick by FirstDown
United States : NFL Week 4
Sunday 28th September 2025 - Scheduled 4:05pm
9:05pm (British Time)
Preview
There is a Thursday Night Football game on deck for the Los Angeles Rams (2-1) and that against a Divisional rival that has begun the season with a perfect record. The scheduling spot does feel a little tough for the Rams having somehow failed to beat the Philadelphia Eagles in Week 3 and with a short week coming up, but Head Coach Sean McVay will be looking for a bounce back performance from his experienced roster.
They should also have the additional focus of facing an unbeaten opponent when hosting the Indianapolis Colts (3-0), a team who have made a surprising start with Daniel Jones at Quarter Back.
Most would have tipped up the Colts to be chasing the Houston Texans in the AFC South, but they are leading the way in the Division.
Wins over the Miami Dolphins and Tennessee Titans are not the most eye-catching, but the Colts have thumped both opponents. They were fortunate to beat the Denver Nuggets when a late flag gave the Colts a second chance to hit a game winning Field Goal in Week 2, but this is something of a prove it kind of outing for them.
Jonathan Taylor has made a really strong start to the season and the Indianapolis Offensive Line have been key to opening up the running lanes, but this is a Rams team that have focused on being able to play the run better than previous years. Most of the attention for that improvement is trying to shut down the Philadelphia Eagles, and the Rams played Saquon Barkley well in Week 3 to believe they can have success against Taylor.
That will change the dynamics for Daniel Jones at Quarter Back, although he is a player capable of tucking the ball away and look to pick up chunks of yardage on the ground too.
He has been well protected early this season, but this could be a tougher test against a strong Los Angeles pass rush and especially if Daniel Jones is throwing from third and long spots. The Rams Secondary have also been playing well thanks to that pressure up front and this is unlikely to be a day when the Indianapolis Punter gets to put his feet up.
While the Colts could have some challenges establishing the run, the Rams should be more effective with the Indianapolis Defensive Line perhaps the least impressive of the units on both sides of the ball. That is not to say the Colts have been terrible, but they are have allowed some big carries and the Rams could be able to use their solid Offensive Line to open up gaps up front.
This is going to be key for Matthew Stafford, especially if Davante Adams is not able to suit up for the Rams.
Operating out of third and manageable spots should allow Stafford to use all of his experience to keep the chains moving, even against this Colts Secondary that have opened the season playing the pass very effectively.
The schedule is tough for the Rams, but this is also feels like the first really big test for the Indianapolis Colts.
Having the hook is always dangerous when opposing the underdog, but the Los Angeles Rams should be focused after the loss in Week 3 and they can make up for that, while also staying in touch with the early pacesetters in the NFC West.
Prediction
Lay the points with the home favourite.
The Pick :
Los Angeles Rams 24-17 Indianapolis Colts
